relation between estrogen and progesterone receptor status with p53, ki67 and her-2 markers in patients with breast cancer
Authors
abstract
background: breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. the purpose of this study was to determine the relationship between estrogen and progesterone receptors with her-2, ki67, p53, and clinicopathological factors in breast carcinoma. methods: 184 patients with breast cancer were chosen and immunohistochemistry was used for expression of p53 protein, her-2, estrogen receptor, progesterone receptor and ki67 in breast tissues. for statistical analysis, pearson's chi-square tes and spearman's rho were used. results: positive staining of estrogen receptor, progesterone receptor, her-2, ki67 and p53 was found in 63%, 53.8%, 54.6%, 56.2% and 42% respectively. also there was reverse relation between estrogen receptor, progesterone receptor with her-2 (p< 0.05), but there was no relation between estrogen receptor and progesterone receptor with p53 and ki67 (p>0.05). also over-expression estrogen receptor was significantly associated with decreased lymph node metastasis and malignancy grade (p< 0.05). also over-expression of progesterone receptor was significantly associated with decreased malignancy grade (p< 0.05). conclusion: breast cancer progression is often associated with alterations in expressions of estrogen receptor, progesterone receptor, her-2/neu, p53, and ki67 and reverse association between hormones receptors and her2 leads to lower or absent hormone receptors in women with her2 positive breast cancers. also positive estrogen receptor status can be associated with better survival in these patients.
similar resources
Relation between Estrogen and Progesterone Receptor Status with p53, Ki67 and Her-2 Markers in Patients with Breast Cancer
Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...
full textthe past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
Correlation of ER, PR, HER- 2 and P53 Immunoreactions with Clinico-Pathological Features in Breast Cancer
Background and Objectives: The most prevalent malignancy among women is known to be breast cancer (BC). Several factors contribute to determining tumor prognosis and treatment strategies. In this study, the frequency and relevance of these factors are discussed. Materials and Methods: This cross-sectional study was carried out on 214 patients with BC, who referred to the Cancer Institute of...
full textEffect of hormone receptors and Her-2 status on metastasis status in patients with breast cancer using logistic regression model
Introduction: Breast cancer is the most common type of cancer and the leading cause of cancer death among women. According to estimates in 2018, the most frequency of cancer in Iranian women was related to breast cancer with 13776 (12.5%) new cases. Metastasis is a complication of this disease that occurs in 1%-5% of patients. The aim of this study was to investigate the effect of hormone recep...
full textMale Breast Carcinoma: An Immunohistochemical Study Of 50 Cases From Iran
Background and Objective: Male breast carcinoma (MBC) is an unusual form of neoplasia, representing 0.7 to 1 percent of all breast cancer cases. Usually, the carcinoma affects patients after the sixth decade. The aim of this study was to evaluate the status of estrogen and progesterone receptors (ER and PR) and prognostic factors (p53 and Her-2/neu) in a series of male patients with breast canc...
full textEstrogen receptor, progesterone receptor, and Her 2 Neu positivity and its association with tumour characteristics and menopausal status in a breast cancer cohort from northern Pakistan
OBJECTIVES To measure the frequency of estrogen receptor (ER), progesterone receptor (PR), and Her 2 Neu positivity and to study their association with tumour characteristics and menopausal status in a breast cancer cohort from Northern Pakistan. METHODOLOGY Patients attending NORI with histopathologically proven diagnosis of invasive ductal carcinoma of the breast were included after providi...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of blood and cancerجلد ۸، شماره ۴، صفحات ۹۳-۹۷
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023